Healthy protein using this motif bind since dimers to the significant groove of your own DNA. Of a lot steroid receptors understand this type of website name.
Proteins with this specific particular motif has a keen amphipathic a great -helix on their carboxyl terminus. One to side of the helix contains hydrophobic teams, always leucine, which might be constant most of the 7th reputation for a couple converts of your own helix. One other deal with include billed and polar organizations.
Proteins using this type of theme join given that dimers on the big groove of your DNA. The dos an effective -helices of every sleeve go into the major groove and you will wrap around the fresh new double helix. Several oncogenes make use of this sorts of theme. （更多…）